APPROPRIATE CONTROLS FOR DIGITAL THERAPEUTIC CLINICAL TRIALS: A NARRATIVE REVIEW OF CONTROL CONDITIONS IN CLINICAL TRIALS OF DIGITAL THERAPEUTICS (DTX) DEPLOYING PSYCHOSOCIAL, COGNITIVE, OR BEHAVIORAL CONTENT

Digital therapeutics (DTx) are software programs that treat a disease or condition.Increasingly, DTx are part of medical care, and in the US healthcare system they are regulated by the FDA as Software as a Medical Device (SaMD).Randomized controlled trials (RCT) remain a key evidence generation step for most DTx.However, developing a unified approa

Many theoretical and experimental studies suggest that range expansions can have severe consequences for the gene pool of the expanding population.Due to strongly enhanced genetic drift at the advancing frontier, neutral and weakly deleterious mutations can reach large frequencies in the newly colonized regions, as if they were surfing the front of

Juhi M Purswani,1 Nitin Ohri,2 Colin Champ3,4 here 1Department of Radiation Oncology, New York University School of Medicine, New York, NY, USA; 2Department of Radiation Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, New York, NY, USA; 3Department of Radiation Oncology, University of Pittsburgh Medical Center, Pittsburgh,

IntroductionThe increase in demand for water resources due to population growth and economic development along with water wastage and a decrease in rainfall, on the other hand, has made it significant to pay attention to water demand and make sound policies.Our country is facing the risk of a water crisis in the coming years, mainly due to its loca